P040

Database for Underwater Biosensor Ligands

A0099 Alexander A. Zamyatnin A.N.Bach Institute of Biochemistry,Russian Academy of Sciences, Moscow

There is a great diversity of different chemical substances found in

the World Ocean. The population of marine chemical substances

contains natural oligopeptides and their analogues. They are produced

by marine living organisms and can be result of human activity.

We are familiar with several thousand naturally occurring

oligopeptides at present and this number is rapidly increasing. The

information on their structures and function is contained in a

specially created database EROP-Moscow (Endogenous Regulatory

OligoPeptides). These substances were elucidated in many marine

organisms: Protochordata (ciona), Chordata (mammalian, fishes),

Coelenterata (hydra, jellyfishes, sea anemones,), Arthropoda (crabs,

lobsters, prawns, shrimps), Echinodermata (sea urchins, starfishes),

Mollusca (clams, mussels, sea hare, snails, octopus)etc. Many of them

are the sources of different toxins and other physiologically active

oligopeptides which can be detected by special biosensors.

Increasing interest in the detection of marine living organisms and

underwater biosensor problem have created a need for improved data

management in this field. The part of EROP-Moscow database contains

more than thousand entries of fully referenced marine oligopeptide

data including primary structure, functions, location along with

relevant literature references. The database has a set of search

tools that allow users to extract data and perform specific queries.

These entries have compiled from scientific literature, cleaned of

errors and enriched with additional structural and functional

information. The grouping of oligopeptides provides a basis for

extending and clarifying the existing structural and functional (e.g.

oligopeptide ? biosensor interaction) classification. This

information is planned to be accessible via the Internet.