Database for Underwater Biosensor Ligands
A0099Alexander A. Zamyatnin A.N.Bach Institute of Biochemistry,Russian Academy of Sciences, Moscow
There is a great diversity of different chemical substances found in
the World Ocean. The population of marine chemical substances
contains natural oligopeptides and their analogues. They are produced
by marine living organisms and can be result of human activity.
We are familiar with several thousand naturally occurring
oligopeptides at present and this number is rapidly increasing. The
information on their structures and function is contained in a
specially created database EROP-Moscow (Endogenous Regulatory
OligoPeptides). These substances were elucidated in many marine
organisms: Protochordata (ciona), Chordata (mammalian, fishes),
Coelenterata (hydra, jellyfishes, sea anemones,), Arthropoda (crabs,
lobsters, prawns, shrimps), Echinodermata (sea urchins, starfishes),
Mollusca (clams, mussels, sea hare, snails, octopus)etc. Many of them
are the sources of different toxins and other physiologically active
oligopeptides which can be detected by special biosensors.
Increasing interest in the detection of marine living organisms and
underwater biosensor problem have created a need for improved data
management in this field. The part of EROP-Moscow database contains
more than thousand entries of fully referenced marine oligopeptide
data including primary structure, functions, location along with
relevant literature references. The database has a set of search
tools that allow users to extract data and perform specific queries.
These entries have compiled from scientific literature, cleaned of
errors and enriched with additional structural and functional
information. The grouping of oligopeptides provides a basis for
extending and clarifying the existing structural and functional (e.g.
oligopeptide ? biosensor interaction) classification. This
information is planned to be accessible via the Internet.